WITH ETOMIDATE, FENTANYL, MIDAZOLAM, PROPOFOL, THIOPENTAL, AND keywords = "PANCURONIUM, ANESTHESIA, PHARMACOKINETICS,

Pharmacokinetics of propofol in adult patients undergoing coronary revascularization. Anesthesiology: The Journal of the American Society of Anesthesiologists. 1996 Jun 1;84(6):1288e97. Open-TCI Billard 1998 Propofol 51 Venous 29e69 40e89 Alfentanil SFAR abstract 1998, poster R279 Open-TCI

keywords = "general anesthesia, pharmacokinetics, Robust closed-loop control of induction and maintenance of propofol general anesthesia, pharmacokinetics, pharmacodynamics, intravenous agents effects and pharmacokinetics of propofol, and to provide a reasonable reference for clinical anesthesia patients and evidence for individual dosage regimens. Comparison of Plasmatic Concentrations of Propofol and Remifentanil During Monitored Anesthesia in Obese and Non Obese Patients. · Sponsorer. Ledande av C Bergman · 2017 — propofol, ketamin. Key words: alphaxalone, Alfaxan, anesthesia, cat, feline, pharmacokinetics, pharmacodynamics, side effects, propofol av G Karer · 2018 · Citerat av 1 — First, the modelling of pharmacokinetics of propofol is introduced.

Propofol pharmacokinetics

Whole blood propofol concentrations … Using propofol as an example, explain briefly the importance of clearance. (also Pharm-97A10, Pharm-95B01) Pharm-00A14 Discuss the roles of the plasma esterases on drugs used in anaesthesia. Pharm-95B03 Give a brief account of drug protein binding and outline its significance. Pharm-95A03 Define Phase I and Phase II reactions in drug metabolism. Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Se hela listan på drugs.com Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations.

Dyck GB, Shafer SL. Effects of age on propofol pharmacokinetics, Seminars in Anesthesia 11:2-4, 1992.. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (GI87084B). Anesth Analg 77:1031-1040, 1993

Following IV bolus administration, propofol (Diprivan) CNS actions are terminated by redistribution from the brain to other compartments. This process occurs with a redistribution halftime in the 2-8 minute range. 2018-07-18 · Like most anaesthetics, propofol is a γ-aminobutyric acid (GABA) receptor agonist. It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has resulted in it becoming the most commonly used intravenous anaesthetic for the past three decades [ 2, 3, 4, 5, 6, 7 ].

av S LUNDEBERG — Som profylax används propofol och betametason under anestesin. Ondansetron är en metabolite pharmacokinetics in children. Paediatr Anaesth. 2004

Thiswasindicatedbyestimates ofelimi-nationhalf-life of1.5-5 handofsystemicclear-ance which exceeded 2021-02-24 · Propofol is known as one of the most potential anesthetics which suffer from limited duration of anesthesia water insolubility. Therefore, in the present study, a formulation of propofol- carboxylic acid-poly [ethylene glycol (COO-PEG)]-b-poly[ D,L lactide (PDLA)]-nanomicelle was developed and its characterization was done by transmission electron microscopy (TEM) and dynamic light scattering Pharmacokinetics of propofol after a single dose in children aged 1-3 years with minor burns. Comparison of three data analysis approaches.

PROPOFOL (2,6-diisopropylphenol) is a water-insoluble intravenous anesthetic that is available as an oil-in-water lipid emulsion with 10% soybean oil (Diprivan®; AstraZeneca, London, United Kingdom). 1 Propofol lipid emulsion has been associated with a variety of drawbacks for which altered lipid emulsion or nonemulsion formulations have been developed.
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Following IV bolus administration, propofol (Diprivan) CNS actions are terminated by redistribution from the brain to other compartments.

1 Propofol lipid emulsion has been associated with a variety of drawbacks for which altered lipid emulsion or nonemulsion formulations have been developed.
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PROPOFOL (2,6-diisopropylphenol) is a water-insoluble intravenous anesthetic that is available as an oil-in-water lipid emulsion with 10% soybean oil (Diprivan®; AstraZeneca, London, United Kingdom). 1 Propofol lipid emulsion has been associated with a variety of drawbacks for which altered lipid emulsion or nonemulsion formulations have been developed. 2

Propofol plasma concentrations were determined from arterial blood samples. Pharmacokinetics were tested for linearity using the ratio of the concentrations at the end of the first and second infusion interval as a model independent criterion. Several linear and nonlinear models were investigated with population pharmacokinetic analysis. 2020-01-17 · The carriers of the polymorphic CYP2B6 T allele received a significantly lower overall and initial dose of propofol. Unlike polymorphism of the UGT1A9 gene, the tested CYP2C9 and CYP2B6 gene polymorphisms are not independent predictors of the pharmacokinetics of propofol.